I think the following seats will switch:
Dem->Rep: VA, IA, IL
Rep->Dem: NY, MD, MA, CA, OH
I think Roy Moore will challenge Riley and keep the Alabama seat red (barely)
I think Murkowski is a weak incumbent in Alaska, but the Democratic party up there is just plain awful.
I haven't looked into the Wisconsin race enough to get a feel for it.
Michigan is also a very viable pick-up for the Republicans if they can find a good challenger.
Colorado also leans/slight Democrat if Salazar retires from the Senate to run for Governor, but I think as a freshman governor, he won't do that.
Everything else should remain the same.
Who do the Republicans have in Illinois that can win? I know Blagojevich is unpopular, but unless the GOP recruits someone from Congress, I don't see how they defeat him. I think Wisconsin and Michigan are more or less the same situation.