If this continues on, it would mean a natural Dem House majority (and control of a bunch of large states) with a major Republican advantage for everything else. Sort of like the 1870's-1890's.
Why does this pattern portend a natural Dem House majority?
Also, looking at the medium-long term for Presidential elections, Texas and Florida are the key. If Democrats can get those two states on their side (along with perhaps Georgia and North Carolina), they can afford to lose the entire midwest minus Illinois.
Edit: Texas flipping is the tipping point though. That's when we likely see another realignment. Florida is also a wild card. Lots of minority growth but also lots of elderly Northeastern and Midwestern white growth as well. It always looks like Florida will vote more Democrat than the nation and then it doesn't happen.