All elections are realigning elections.
Uhhh... no. Except for 1980 and 1992, in which the President elected in the previous election lost by a large margin, the electoral maps are fairly similar between years. If five or fewer states move one way or the other, there is no real realignment. Even in 2020 the difference from 2016 was five states, and the most likely three of the states that did move from Trump to Biden would have been enough. 2020 looks like about as status-quo an election, one that the personality and performance of Donald Trump decided for the Presidency more than anyone else, as there ever has been. Voters casting off an corrupt, erratic, or incompetent incumbent is no realignment. Open-seat elections are more likely to have change.
"1980" reflects a change in American cultural life, with the rise of the Religious Right whose economics are best described for the proletariat as "Suffer in This World on behalf of the owners and managers so that you may receive your rewards in the Next" (opinion: anyone who pushes that deserves to end up in the part of Hell that most resembles an ante-bellum plantation in the old American South... as a slave), and "1992" reflects the separation of the Eisenhower/Rockefeller Republicans from the reactionary, racist Southern agrarians with whom they had little in common.
Will 2024 be a realigning election? Looking at prior elections in which the President or his VP successor ran for another term...
elections of 1956, 1984 (only five states 'moved'), 1996, 2004, and 2012 suggest more of the same.
1976, in which Ford would have been a continuation of Nixon years without Nixon's "dark side" is likely irrelevant.
1992 is imaginable if one sees Joe Biden as a tiresome third term of Barack Obama for all practical purposes. We shall see.
1980 suggests a Presidential failure, but really... the political culture changed as the New Deal coalition fell apart and the Religious Right won over the Mountain South.
1964 and 1972 represent the losing Presidential candidate winning the nomination by winning the more radical wing of the Party, only for the incumbent's Party to cast that candidate as a dangerous extremist out of touch with mainstream America. Paradoxically the losing Party of that year nominated a moderate in the next election... and won. The problem with that analogy is that there is no large 'moderate' wing in the GOP.
Open seat? Anything goes.