Knowing the G.O.P, when next election comes, they'll nominate Ted Cruz or some other Reactionary-Lite Conservative and lose. Come 2024 though, I think they'll nominate someone more moderate, but still a Conservative. Can't put a name on that person, because they're likely still in the state legislature.
If they nominate Ted Cruz he'll destroy Hillary Clinton in a landslide like this
I do not see Ted Cruz ever carrying Washington, Oregon, Michigan, Virginia, New Hampshire, and ME-1. He is a very poor fit for all of those states. Also, Cruz would have trouble in North Carolina, Georgia, and Florida as well.