There is probably more fatigue with Democrats than Republicans. The problem is Republicans have a few major problems that make that fatigue a better alternative to many demographics in the voting booth. I think most people across all demographics want a fiscally conservative government with mostly conservative views on the economy, national security, and terrorism. It's just the social views, religion, some anti-science stances, and general comments against people who aren't straight white men that instantly alienate 45-50% of the country no matter what.
Let me break this down again:
Religion: Yeah Republicans have to pander usually to Evangelicals because its their base in the Deep South. Yet, Trump really didn't pander to Evangelicals and he still won the primary.
Anti-Science-I don't think Republicans are anti-science. I mean people thought we were gonna have an "ice age" when Carter was President. It never happened.
General Comments about people who are not white men-As I said before Trumps comments about Mexicans are unacceptable. I think the party as a whole is starting to understand that some of their rhetoric mostly against Latinos was offensive in the past except for Trump. The party was against Trump's proposed Muslim ban for example.