49-state sweep. Holdout?

[100% pro-life no matter what]

Oklahoma in a Democratic landslide and Massachusetts in a Republican landslide.

[100% pro-life no matter what]

Unlikely Hawaii since it has a Republican incumbent bias, which is probably the scenario of a 49-state landslide.

If it's a Democrat incumbent getting blown out, Hawaii would be the holdout.

Yes, though this scenario is much less likely to happen than a GOP re-election.

I'd say for the Dems: MD, NY, MA, RI, and for the GOP: OK, ID, UT (I doubt WV with its Dem history, particularly older voters who could be swing in a landslide.)

Although, West Virginia could be the answer in a Trump 49-state loss.  The answer is clearly that it depends on why one party got 49 states in the first place.

[100% pro-life no matter what]

Cruz vs. Clinton: Utah (R), Rhode Island (D)
Trump vs. Clinton: West Virginia (R), Hawaii (D)
Kasich vs. Clinton: Wyoming (R), Massachusetts (D)
Cruz vs. Sanders: Alabama (R), Vermont (D)
Trump vs. Sanders: Alabama (R), Vermont (D)
Kasich vs. Sanders: Idaho (R), Vermont (D)
Generic R vs. Generic D: Oklahoma (R), Rhode Island (D)

Now, these are not necessarily what would have the biggest margins, but just what would be the hardest to flip.