Hassan running for Senate seems like a stupid move. Had she stayed put, she probably was in pretty good shape for reelection. Instead, she is running against a fairly popular incumbent senator, and her race is no sure thing, and a good chance the Republicans take the Governor's mansion too.
This would be a crazy parallel to 2002:
2002: Shaheen doesn't run for reelection for Governor, runs for Senate instead but loses to John Sununu, Governor's mansion flips to the Republicans.
2016: Shaheen's daughter runs for Governor after the current one leaves to run for Senate, but the incumbent Republican Senator wins, and Shaheen is beaten by John Sununu's brother Chris Sununu.