I find the results for Alachua since 1960 interesting as well. In 1960, the county went for Nixon, while surrounded by a sea of JFK counties on the panhandle!
Jump to 1968. Alachua was one of only three counties in FL to go for Humphrey. It was surrounded by a sea of Wallace counties on the panhandle.
Jump to 2000 and 2004. Alachua voted Dem among a sea of Bush counties!
Any explanations for these trends in Alachua since 1960?
IIRC, Alachua has a large black population. Counties with large numbers of non-voting blacks were fairly likely to vote Republican in 1960 (BTW, Alachua voted for Thurmond in 1948 and Eisenhower in both 1952 and 1956) . After the Voting Rights Act was passed in 1965, blacks could vote in large numbers, making Alachua solidly Democratic.