When it comes to general election match ups Hillary Clinton leads the Republicans we tested against her by margins ranging from 4 to 7 points. Chris Christie comes the closest at 46/42, followed by Rand Paul at 49/43 and then Marco Rubio at 49/42 and Paul Ryan at 50/43. We've consistently found that Christie would be the strongest Republican candidate but the problem for him is that Obama voters (42/24) like him better than Romney voters (36/31), which could making securing the nomination a problem.
Joe Biden does on average 6 points worse than Hillary Clinton in general election match ups against the Republicans. He leads Rubio (46/44), Ryan (48/45), and Paul (47/43), but by narrower margins than Clinton in all three cases. And he actually trails Christie by a pretty large margin at 49/40.
http://www.publicpolicypolling.com/pdf/2011/PPP_Release_4313.pdf