WV. I felt like some counties that held out in 2008, like Braxton and Webster, should never be lost by a Democrat.
I remember first looking at the WV results on election night and being pretty shocked. I knew Obama would slip, but I wasn't expecting an all-county shutout.
The first clue of that was Kentucky; counties that went >60% Kerry were showing as >70% Romney. He nearly even won Elliott!
I guess I was disappointed in PA; the GOP's gerrymandering worked really well in the House races (suburban Philly's been sliced into an unholy abomination), and thanks to Romney's last-minute money dump and Obama mostly ignoring the state, it was closer than it should have been.