Iran having nuclear weapon is not a threat per se, because they are never going to use it. We can say a lot about Khamenei and other ayatollahs, but they are not suicidal. Iran want to have a weapon mainly to have U.S. get the f**k out. Not suprising, considering how much evil U.S. did for this country, even being responsible for Aytollahs rise to power. There is pretty broad consensus among both regime side and opposition that Iran should have weapons.
The only problem would be probably nuclear arm race in the region, as Arab state would get crazy with such armed Tehran. Not suprising again, since Americans were idiotic enough to destroy the bulwark against Iranian influence, Saddam's Iraq used to be.
I would be MUCH MORE CONCERNED about Pakistan, which already have nuclear weapon and is unstable as all hell. But, again, who effectively destroyed Non-Prolifeation?
So stop complaining and dreaming, my American friends.