I mean, few credible voices would endorse Rome defeating Alexander.
In the last years of his life Alexander built a navy (that was used to reduce Athens in the Lamian War) and it's speculated that he was planning an invasion of Magna Graeca, Italy proper and/or Carthage. Livy speculates about this happening and has Rome beating Alexander, because of course.
Haha, I have read that, and I did laugh when I came across that primary source, whenever that was. I wouldn't even necessarily put my money on Alexander
conquering Rome, as it was indeed starting to gain its strength and its patriotic fervor/ability to replenish its forces and persevere were damn near unrivaled, but it annoys me when people look back on Rome's dominance as inevitable; I find that it is a huge insult to the Romans, who defied quite a few long odds and easily could have never become the global civilization they were. Alexander could have at least confined them to a client state, IMO, and I do believe there was a good chunk of time after his death where several Hellenistic powers, in their own rights, were more powerful than Rome.