The biggest issue is how almost perfectly Senate race voting has become correlated with presidential voting.
Who are the people who would vote for Trump but for a Democratic Senate candidate?
Obama-Trump voters in rural eastern Iowa who still mostly identify as Democrats but like Trump specifically (so probably also Trump-Finkenauer/Loebsack voters), Trump-Kelly voters in rural western Kansas (that's where her win really came from - not Johnson County!), lots of Trump-Bullock voters from 2016 in Montana already, Trump-Golden voters in ME-02, the few surviving Ancestral Dems in North Carolina if Cunningham can pull off an Andy Beshear-level performance.
No idea who this would be in Texas or Georgia, though.
Memes and jokes aside, there will certainly be more Biden-Cornyn and Biden-Perdue voters than Trump-Hegar or Trump-Ossoff.
That sounds correct, but do we really think there will be that many in either category?