Ticino's politics are completely sui generis. Principally, in recent times, they have been marked by two major factors that are a sense of alienation and neglect from the rest of the country, and tensions around the number of Italian frontalieri who work in the canton and get blamed for lowering wages, unemployment, all the usual basically. In particular this has driven the growth of the the right-populist and regionalist Lega dei Ticinese.
The irony being I'd bet whatever you want that many Italian frontalieri vote Lega (Nord, not dei Ticinesi) and blame immigrants in Italy for all the usual.