Im not saying it would happen,but in theory it is possible.
In theory, Bernie Sanders could win a 50-state majority plus DC.
In practice, Ted Cruz and his Evangelical-friendly style is a perpetual turnoff to the moderate Republicans in New England and the Middle Atlantic states, and on the Pacific Coast, as well as to the unionized Midwestern voters in Wisconsin, Minnesota, and Michigan. The backlash against religious conservatives began in 1992 in response to Pat Buchanan's speech about Culture Wars. New England and California had been rebelling against the GOP on these issues for a while, but it broke loose in 1992, and today, these states are a Democratic as the South is Republican.