As far as voters (because that's all that really mattered then): white Yankee urban business owners in Columbia and Charleston, with perhaps a sprinkling of poor Appalachian white trash in places like Oconee and Pickens County.
Was the Republican Party ever relevant in upstate SC back then? Looking at the maps, there's a fairly abrupt transition from Republican overperformance in northern GA and western NC to basically no Republicans just across the state line in SC.
Seems like the Appalachian part of SC would have just been populist Democrats.
And anyway, SC had a very elitist political culture and many "poor white trash" would have likely been excluded from the franchise due to poll taxes and literacy tests.