The dynasty issue could be potent, but with the Republicans pleading for Jeb to run, I don't think they'll really have any room to talk, especially considering she's only the second Clinton whereas he'd be the third Bush.
As for the intense negatives, that's true as well. But I think that would eventually be true for any Democrat. Whoever the Democratic nominee ends up being, the right wing media/talk radio will gin up tons of hatred somehow and make them unacceptable to ~45% of the country. I mean, look at Al Gore and John Kerry. They're about as inoffensive as you can possibly get, but the right managed to make them into Satan incarnate.
I'd almost rather see Hillary run against some fresh blood than another Bush. If it's a Clinton-Bush match-up, then queue the Millennial "they're all the same, maaaaaan" attitude, the youth largely sit it out and we have one of the lowest turnout presidential elections in recent history.
