How would Tunica be a better place to gamble than, say, Biloxi/Gulfport, which has more or less the same quantity/quality of casinos, but with the added benefit of the beach and being not too far from New Orleans?
Six hours further north for those getting there by car from points north. You can save two travel days in your journey to a full fledged land-based casino as opposed to those riverboat casinos Missouri and Illinois allow. Also the relatively low gaming taxes allow Mississippi casinos to offer better payouts (not that they necessarily do). The high rollers are going to go someplace other than Mississippi in any case.