Depends on what you mean by radical. For instance Lexington County is definitely a hotbed of fiscal radicalism, but not of social radicalism, especially in comparison to the upstate.
Meh, they usually go hand-in-hand.
Well, it's not the case you'd find an openly pro-choice Republican officeholder here in Lexington County, but you'd have to go the upstate to find the crazies who would think it would be a good thing for the General Assembly to pass a law that would ban abortion at six weeks and spend time and money in a fruitless defense of that law in the courts.