1. Go with a very liberal candidate that is able to work well with a Dem Congress. Someone like Warren would be great.
2. The big danger would be Democrats permanently losing the Midwest and northern white working class voters if they don't at least try. Nominate a populist outsider like Bullock. He will surely go down, but try to keep losses in the rust belt containable, with the expectation that losses in the suburban vote will not be permanent. That way Democrats will still have a foundation in the rust belt in 2020.