That's what I have been thinking for a while now. Really, the parallel Reagan-Bush41=FDR-Truman, Clinton=Ike, Dubya=JFK/LBJ, Obama=Nixon works impressively well. Following that logic, a moderate Republican should win in 2016 and then be defeated in 2020 by a progressive Democrat who would achieve the realignment. That's going to be pretty fun if it happens. 
Yes, I've thought about that comparison a lot. It's eerily similar, especially the Ike/Clinton comparison. Both were popular moderates who broke up a period of presidential dominance from the other side. They both presided over happy times in our nation's history and didn't rock the boat, but set the stage for their party's comeback in the near future.
