OMG, this would be a disaster. I can see the MoveOn.org George Wallace ads running already. Barbour has such a deep southern accent, and it will be proof positive to some that the republican party is racist. It's a shame because he's obviously not, but still...
Speaking on other southerners...
Ditto Jindal, except without the racist angle. I love the south and I love southerners, but if I think "corn-po" in my head when Jindal speaks, then I know every single moderate and liberal person is thinking even worse. Also, Rick Perry sounds identical to Bush when he speaks - identical. This is something that gives Romney and Thune a gigantic advantage. Honestly, I wish we could run Chris Christie against Obama though...
Chris Christie is too fat though. He has to lose some weight first.