No. 2010 (and probably 2014) were big GOP wins because the Democratic coalition does not turn out in midterms/off years.
In addition, Hillary is a stronger candidate than any of the GOP presidential candidates could ever hope to be.
The two are not correlated at all, anymore than 2010 signaled a Romney landslide, or 1994 signaled a Dole landslide.
Umm, didn't 2006 signal the Obama landslide in 2008 It certainly gave the Democrats a lot of momentum heading into 2008.
Hillary certainly has a lot of popularity, and it could be enough to beat any unpopularity with political issues like Obamacare.
But a generic no-name Democrat like O'Malley, could have a far more difficult time if issues like Obamacare remain unpopular; and Obama's popularity remains below 40%.
I don't know why "young people and minorities" don't turn out in mid-terms, maybe they just don't care about voting or politics unless there is a cool, handsome bi-racial handsome man running for president. They didn't really come out for Gore or Kerry, who is to say they will come out for Hillary
1. Hillary Clinton already has the Obama campaign apparatus.
a. That is the slickest campaign apparatus in decades. It is as savvy about the technology of electioneering as ever.
b. The campaign apparatus is not shoring up the President's approval rating. President Obama needs no longer campaign for the Presidency. Thus the President's approval rating need not be close to 50%.
2. Most of the vulnerable D seats are in the states that Barack Obama lost badly in 2008 and 2012 -- Arkansas, Louisiana, West Virginia, South Dakota...
3. Although midterm elections usually constrict D voting, Presidential elections usually give a sharp D advantage.
4. So far, President Obama has done nothing that discredits himself or his Party. There are no scandals, no diplomatic or military debacles, and no economic collapse. The President has done nothing to make an economic collapse likely. He isn't Dubya on economics, he isn't Carter in foreign policy, and he isn't Nixon in ethics.
5. Should the Republicans win the Senate, then expect the Republican Party to bring about dozens of pieces of right-wing legislation from a nationwide Right To Work (for much less) law, abolition of the minimum wage law, tax shifts that punish everyone but the super-rich, abolition of welfare, privatization of everything that some monopolistic profiteer could want, educational 'reforms' to impose school prayer and creationism, and maybe wars for profit.
People seeing the prospect of a Christian and Corporate State might decide that such is to be stopped, by elections if necessary and possible because other methods are more dangerous or difficult.