Not that I think his nomination is likely, but he's the most promising Hispanic that the Republicans have at the moment. I'm not so much interested in him specifically, but how Generic Hispanic Republican would do in Generic Presidential Election. Bush won about 40% of Hispanics in 2004, so in a 50/50 election, would Rubio win a majority? If so, how large a majority? Would it be enough to put some exotic targets (say, California) in play?
No more certain than the idea that because of his ancestry that Barry Goldwater would pick up a big chunk of the Jewish vote in 1964!
Cuban-Americans have been drifting away from the Right as Fidel Castro becomes less relevant, much as happened with Chinese-Americans whlo used to be heavily Republican in response to the extremist ideology of the pre-1970 People's Republic of China.