It's possible, but unlikely.
The advantage for Democrats is that it's unlikely that the same party will have an awesome 2016 and 2018.
The party that does well in 2016 Senate races will likely win the White House, which means they'll probably not have a great midterm. That said, Republicans did so badly in 2012 that it won't take much to pick up seats in 2018. Democrats will be defending 25 Senate seats. Republicans can win only a third of the races, and they'll pick up three seats.
The map is not the biggest determinant as we have seen, it can limit (2010) or enlargen a wave (1980), but the fundamentals still control things. However in this situation, it is not like the GOP has anything left to lose in Class 1 as Dems have gained seats every cycle since 1994. There are five double digit Romney states with Democrats (MT, ND, MO, IN, and WV) and five more sitting in winable swing states (FL, VA, OH, WI, PA if Casey retires). UT, WY, TX, TN, MS and NE are safe, AZ is surely likely GOP in a lower turnout midterm, leaving only NV (and Dean Heller is hardly a push over).
Since Wicker cannot be NRSC chair in 2018 as he is up (that is a rule no?), I hope that Moran is put back in charge again. Ensign came back for a second stint in 2008, though largely because no one else wanted the blame for that cycle.