The NEW PRESIDENTS era...

[JohnFKennedy]

The following has occured since 2000 until 2016:

42. Clinton/Gore
43. Bush/Cheney
44. Kerry/Clinton/Clark
45. Clark/Rendell
46. Giuliani/Rice
47. Rice/Owens

The following presidents have also died:
Carter
Ford
Kerry

Only Bush 41, Clinton, Bush 43, Clark, Giuliani and Reagan are left. Reagan is now 105 years old.

Rice has won her own term over Rendell/Edwards. Now, since she declined re-election, Owens/Inhofe is running against Edwards/Warner. Owens loses to Edwards 230 to 308. Rice had an uneventful term. What will the new President Edwards bring?

prosperity . Highly unlike Reagan living to 105 years old methinks.

[JohnFKennedy]

Presidents I have covered:

43. Bush/Cheney-- Cheney dies on May 5, 2011
44. Kerry/Clinton/Clark-- Kerry died on November 5, 2005
45. Clark/Rendell--Clark died on December 2, 2019
46. Giuliani/Rice-- Giuliani dies on June 29, 2020
47. Rice/Owens-- Ford dies on April 18, 2018
48. Edwards/Warner-- Rendell dies on October 5, 2020
49. Owens/Coleman-- Bush 41 dies on March 4, 2021
Only ex-presidents left living are:
Reagan (109 years old)
Clinton (74 years old)
Bush 43 (74 years old)
Rice (68 years old)
Reagan has become known as the God of the Republican Party, always staying alive.

Owens (now 70 years old) and Coleman (71 years old) represented a good old fashined ticket. Presidents have happened. Election, VP took over, death, war. Yet we will always have Democrat and Republican and maybe even an independent leader someday.  
The End

err Edwards isn't listed as alive yet you haven't said he dies, I think your scenario is incredibly unlikely btw lol.