What's holding me back on WY is that it's so small. Consider the possibility one of the Fortune 500 tech companies decides to open a "Grand Teton" campus in WY down the road. That alone could flip the state without anyone who currently lives there changing their vote.
Spot-on.
And I’d say this actually goes for the other sparsely populated plains/mountain states as well. The reason Democrats are so disadvantaged in the EC and Senate is that their voters are largely isolated to a handful of major urban centers in a handful of states. If they started spreading out for whatever reason, that could dramatically shift the politics of some of these small states pretty much overnight.
Also, the question assumes there will even be a GOP in 100 years. Once the Baby Boomers die off, they will be in serious danger of extinction unless they change radically, because I don’t see Millennials and minorities suddenly becoming conservative Republicans. The demographic and religious trends are not at all in the GOP’s favor right now. At the very least they will no longer exist in their current form in 100 years, and it’s possible a major re-alignment will occur by then.