Wyden seems like the Democratic Senator most interested in working across party lines to pass legislation, and he's fairly liberal. Idk if he's a "liberal lion," but I could see him as the next great deal-maker.
A little off-topic, but with Harkin, Levin, and Rockefeller all retiring, Leahy will have 12 years on the
next most senior Democratic Senators (Mikulski and Reid). There are only a handful of Senators first elected in the 70's or 80's left in either party, and it wouldn't surprise me if all have retired by 2022.