Yes Sen. Mark Meadows is definitely right. It's all about religion and culture. New England is a place that puts particularly high value on reason, education, science, social science, etc. etc., whereas the South has been reflexively religious and conservative in culture.
This is one of the main reasons why I don't buy atlas wisdom that New England will trend Republican because it's fairly white.
Does your characterisation of Yankee New England culture apply when it was the region of Coolidge, Lodge Sr, Platt and Aldrich or is it just because most New England states have tended to vote for the party/candidates you agree with over the last few decades?