One of the major problems? Yes, I realize theories like this will have other (intellectual) caveats, but I think you've hit the main nail on the head, really.
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I'm curious (I've been writing too long to try to think right now
), but what other major problems do you have in mind?
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The same problems that all philosophical assertions about what cannot be directly observed have. That one can not really "know" what is being talked about, only reason that this is how it probably is and construct theories with some predictive power. It is still quite possible that some intelligent being designed the world.