Two things could conceivably get her a surprising majority there: 1) Serious anti-republican economic backlash, 2) Husband campaigning effectively on her behalf. The first is not unlikely - the state is abysmally poor and getting worse off, relatively speaking, in the right-wing economy.
I would add a conservative running as an independent to that list. I think that it is conceivable given a Guliani or even McCain win in the GOP primary that a more conservative candidate would run as an independent.