I think the commission could produce something like this:
https://davesredistricting.org/join/3ad4c15b-fadd-4eb7-ae12-70b1ec3ab71cIA-01 and IA-02 don't change that much. Both of them voted for Trump, the former by about 5 and the latter by about 4. Hinson and Miller-Meeks will start out favored in 2022, but one or both could certainly lose in a blue wave.
IA-03, still centered on Des Moines, becomes a lot bluer at Biden +7, as it loses rural areas and gains Story. This seat is within reach for the GOP in a good year, but Axne should be favored most of the time. Even Hillary won it by 4.
IA-04 is even redder than the current version. Especially with an incumbent who isn't Steve King, this seat will be Safe R for quite some time.