In terms of actual election results, Southern California minus LA County (and also minus Ventura and Santa Barbara Counties as you stated) in recent decades has been most similar to Colorado among all states. Not too far off of New Mexico, too. Not really that similar to Nevada or Arizona, although the trends are somewhat similar to Arizona. That might come as a surprise.
Demographically of course it has more similarities to Arizona and Nevada. But then again places like Orange County and San Diego are totally different from anything in either Arizona or Nevada. Only the Inland Empire and Imperial County bear some resemblance to them, and even then they aren't the same.
You don't think Orange County is similar to Maricopa County?