Such a breakup would condemn England & Wales to eternal Conservative rule.
A quasi-independant Northern Ireland seems likely in the next 2 decades - the real challenge would be getting the Northern rump state to willingly unite.
These DUP voters are almost as bad as the US Bible Belt.
Usually decolonization and loss of territory has then coincided with increased support of Labour and the welfare state; see the decolonization of India and Clement Atlee’s reforms, that wouldn’t be possible if the black hole that was the Indian subcontinent wasn’t gone.