For those who don't support states rights, look at it this way: state politics affect you more than national politics, and it's much easier for you to have a say in and influence state politics than it is for you to influence national politics. If you don't like a state law, it's much easier for you to lobby for it to be repealed than it is for a national law. When the Federal Government trumps states rights, they're taking away your power to influence the law.
This is simply not true. By and large, state governments are far more controlled by special interests than is the federal government, and state laws are much more difficult to repeal than federal ones as a result. It is true that state governments act more, but this is merely the direct result of them having authority over more domains and fewer restrictions on how they can exercise that authority, as well as, in most states, one party possessing long-term dominance over state government.