Aside from Rick Perry shooting his stupid mouth off last year, I think the only notable secession movements have been in Alaska and Vermont. In the former's case, the AIP nosedived after Walter Hickel's term, and now they can't break 1% of the vote in gubernatorial elections. In the latter case, the hubbub (if you can even call it that) died down immediately after Bush left office, and the guy they gave two thirds of the vote to took over.
Uh, both of those secession movements are still very much alive and active.
The AIP isn't really a secessionist movement nowadays: they just really dislike the Federal Government. SVR lost a lot of support after its ties to neo-Confederate groups like the League of the South were revealed, and haven't been very active since Bush left office. Both organizations still EXIST, but they aren't particularly active at the moment and have only remote chances of success.