You'll still have dead-enders like Cruz and Paul who won't vote for it because it doesn't cut spending [enough].
That's true, but their end goal is still the same. They are just sidetracked by personal ambition and/or unrealistic ideological purity.
To be honest, I don't see how the GOP can get anything meaningful accomplished if things continue as they are. Their POTUS is completely disengaged and Congress is in a vise between the Tea Party fundies who have zero interest in governing and the purple state Republicans who know their voters aren't going to be enthused about an agenda that offers absolutely nothing to anyone who is not in the 0.1%.
Putting aside healthcare and tax 'reform,' what exactly is left for them to do? These two big ticket issues are naturally difficult, but will the GOP's other smaller agenda items be as difficult to unite the caucus on? When it comes to deregulation, for instance, their biggest issue seems to be getting Democratic votes, which may not even be possible due to the position Trump has put them in.
They can do an infrastructure bill. It's highly likely it'll be a toll roads tax credit to corporate entities giveaway but God knows the public demand for some kind of infrastructure Bill is certainly there.