Michigan could be a candidate here on the Republican side.
The state population growth is stagnant and it doesn’t have any hubs where liberals are moving to (Ohio has the Columbus metro - we’ll see just how crucial this for the November Gov race, Minnesota has the twin cities, Iowa is elastic like crazy, etc). I also don’t suspect that the national Democrats will make a big push for fair trade policies in the coming decades (though this has yet to be seen).
washtenaw (college land) and grand rapids kind of
Don’t know much about Grand Rapids but I don’t count college towns since they’re a constant in any given state.
kent county has typically been strongly GOP but it could be changing, obama won it for the first time in 50 years in 2008 by less than 1% and in 2016 hillary came really close to winning it. it's growing pretty fast too
washtenaw attracts like a LOT of college people though cuz of umich and other colleges as well
but yeah compared to the rest of the state it doesn't look great for democrats