In terms of KY-03, it should be noted that KY’s own redistricting guidelines, as adopted in 1991, explicitly requires that “communities of interest” be kept as intact as possible. I think any attempt to redraw KY-03 into multiple R-leaning districts will likely not survive court challenges due to the aforementioned guideline.
In terms of Maryland, someone posted elsewhere on this forum that drawing a 8D-0R map would likely jeopardize Steny Hoyer in a primary.
An underreported story as far as Kentucky goes is that trends for Republicans are actually kind of bad in the Lexington area, enough that they felt obliged to put Frankfurt in KY-01 and got kind of messy in the state leg. maps. If these trends continue (massive "if" here), Republicans might already have to make things fairly ugly in Lexington and may not want to go full throttle on Louisville.
The smart thing would be to pull KY-06 down to the blood red rurals by the Tennessee border.