International COVID-19 Megathread (user search)
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Author Topic: International COVID-19 Megathread  (Read 456810 times)
Hollywood
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Posts: 1,732
« on: November 06, 2020, 06:34:36 AM »

So a strain has mutated in Denmark that jumps from minks to humans, forcing officials to cull the mink herd.  Terrible news.  They were studying coronavirus in Wuhan for its ability to attack the same cells as HIV, and they observed its potential to avoid antibody responses like HIV.  If it can quickly mutate while jumping from animals to humans to animals, doesn't that put the breaks on vaccinations being a bullet-proof defense that can be successfully repeated?
https://www.theguardian.com/world/live/2020/nov/06/coronavirus-live-news-us-records-global-record-102000-new-cases-as-world-suffers-highest-daily-deaths

This is looking like a repeat of pandemic history in Europe and the Northern US with Covid-19 making a return in the temperate latitudes with the arrival of dry air in the winter months.  I took a look at some of September and October weather records for the areas currently being hit hardest by the virus, and it appears drier areas are correlating with increased spread.  I think it's safe to assume that seasonal patterns of virus spread like we saw with influenza applies to the current situation.  The introduction of a novel virus has been associated with terrible resurgences during fall and winter when the population hasn't had enough exposure during the last winter and recent summer, while spread during summer months is associated with more tolerable viral rates and mortalities.  This is according to a few studies done on the 1918 pandemic showing spread in Denmark during the summer brought about much less severe consequences during winter. 
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0238339

“The strong seasonality evident in mortality records from mid‐latitude locations suggests that climatic factors may amplify cold‐season death rates.  As respiratory mortality exhibits the strongest winter peak of all broad mortality categories,3 it has been suggested that influenza and related mortalities may (significantly or perhaps even entirely) account for the winter mortality peak.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910181/

“Exposure of mice to low humidity conditions rendered them more susceptible to influenza disease. Mice housed in dry air had impaired mucociliary clearance, innate antiviral defense, and tissue repair function. Moreover, mice exposed to dry air were more susceptible to disease mediated by inflammasome caspases.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561219/

 
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Hollywood
Jr. Member
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Posts: 1,732
« Reply #1 on: November 07, 2020, 04:27:06 PM »

Coronavirus Mutation in minks could threaten Vaccine Efficacy. 200 people have been infected with the Mink-linked virus.  "Researchers at Copenhagen’s Statens Serum Institute received lab results that many had long feared. A mink-related coronavirus appeared to be less affected by the Covid-19 antibodies from several people who’d previously been infected."
https://www.scmp.com/news/world/europe/article/3108909/coronavirus-mutation-minks-could-threaten-vaccine-efficacy

Recently, we found out that a study of 87 recovered Covid-19 patients retained inactive particles and proteins of the virus that are lying in the gut.  Animals studies over the last decade discovered that these proteins can eventually mutate in the guts of Minks and feline cats to produce a more deadly species of the virus.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168282/
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