It's worth noting that FOX said tonight that Manchin implied that he is considering switching parties
Can't see it happening, especially if McConnell stays Senate Republican Leader. I hear the two really hate each other as people (IIRC it has to do with college football rivalries). If, say John Thune replaces McConnell, maybe he could become an Independent and caucus with Thune, but the people of West Virginia are used to him being a Democrat. He is very pro-life and pro-coal, but he still endorsed Clinton.
And, Justice won in West Virginia.