If Joe Biden was the Democratic Nominee in 2016, do you think it would be much more difficult for him to win given that the last time Democratic Presidents were elected back to back was prior to the Civil War?
What about FDR->Truman? I know that he basically became an incumbent, but he still held his own in 1948 after
16 years of Democratic rule. That is as good a test for the idea of party fatigue as any. But, I think Party 'fatigue' is less of a problem than maybe some people think it is, but all things considered, Biden would have a much easier time taking on Trump than Hillary, who was getting hit with extraordinary levels of negative media attention in relation to her emails, in addition to endless self-made scandals coming home to roost. She was far from an example of an "average" candidate with an average number of issues.