No, just the end of pretty much all of Hillary's domestic agenda.
Really, how much was she going to get done anyway with the House in GOP hands? Obama/Democrats had a fairly nice Senate majority for 4 years with Republicans in the House and Congress was essentially useless during that period. I'm unsure why Republicans, who are already planning to obstruct her agenda and have convinced their base she is a criminal that needs to be locked up, would work with her on anything significant from her agenda.
I'm not saying it's useless to have a Senate majority, it's certainly not for multiple reasons, but I always understood the key to major policy achievements was complete control and not divided control.
Also, I don't see how this is RIP majority. We just need 4 seats if she wins, and that is still perfectly doable.