Unless something changes, the answer is yes --- the Northeast is inaccessible; they've lost Virginia, New Mexico, Colorado, and Nevada; Florida, Georgia, Arizona are going quickly; and the Midwest is stubborn (i.e. PA).
The good news, however, is that they can effect the necessary changes. They just need to realize that they need to change because 2012 didn't do it.
In florida we have a Republican governor, a supermajority republican house, a republican senate majority, a republican senator, and a majority republican hose delegation. But tell me again how Florida is out of reach for republicans....