No candidate in 2012 will be "unstoppable". The party is wayyy too hacked up and divided for anyone to possibly unite it in it's current muddy incarnation. Tea Partiers will despise any "establishment" candidate. Sarah Palin/Mike Huckabee will be gettin' amens from flag-wavin' authoritarian Southerners while Gary Johnson or Ron Paul or some other tin-foil-hat-wearing dude will fire up Western conservatives and run a stick-it-to-the-man campaign. The North will pull for some phony, party-line guy that they percieve to be a "moderate", probably Romney, or perhaps Pawlenty, or maybe both! 2012 is going to be the Republican's 1968: an absolute mess that will leave a lot of people pissed off and packing their bags. I am looking forward to it, though, as these things need to happen once in a while for the government to sort itself out, and the fact is, the current edition of the Republican Party does not know what it stands for--it has become a haven for lots of people who do not know what republican is, what a conservative is or even what they themselves are.
I think Thune could unite the Tea Baggers and the Religious Right. If so, he will be unstoppable in the primaries.