She has no defense. Her husband is the white Bill Cosby and she basically unearthed a scorched Earth policy to defend him.
As far as what she'll say, if attacked, is something along the lines of it being personal. We all have personal challenges, etc. Try to humanize it and implicate Trump in a way for being a bad man for even insinuating anything -- maybe even get a swipe in about his challenged personal life.
Honestly, I can’t believe that Bill’s affairs are still a hot topic. The Lewinsky thing is already known and long over. The fact that we a have a Republican nominee who insults all kinds of people and who asks why nukes can’t be used is of much more importance than a few mistresses years ago. The rape claims are ridiculous without any proof who are made up by people who only seek public attention at the expense of others (in all fairness, I also doubt the rape accusations against the Trumpster are true).