On the Democratic side, Patrick Murphy is a huge contender. People thought the guy was a perfect choice for Senate in 2016 on account of an impressive win in a strongly republican year in a decently republican district, but as a General Election candidate was just a massive flop.
For Republicans, it's hard to beat George Allen, who probably would've run for President in 2008, only to be unraveled by "macaca".
Murphy would've pulled it off if Marco hadn't returned.
Speaking of returning people who shouldn't, Evan Bayh.