I can't find definitive information on the full ancestry of Kennedy or Reagan, but it looks like Wilson, Kennedy, Reagan, and Trump are the only four Presidents not to have any pre-Revolutionary American ancestry.
On the Ethnicelebs website, it says the same thing for Wilson, Kennedy, and Reagan:
https://ethnicelebs.com/woodrow-wilsonhttps://ethnicelebs.com/john-f-kennedyhttps://ethnicelebs.com/ronald-reagan“All eight of [name]’s great grandparents were born outside of the United States, a rarity among American Presidents.”
So that’s consistent with at least Kennedy and Regan likely not having any American colonial ancestry. With Wilson, at least some of his great grandparents presumably would have been born before 1776, so it’s less clear.
But I just went to geni.com, and here are the profiles of Wilson’s grandparents:
James Wilson: born in Northern Ireland in 1787:
https://www.geni.com/people/Judge-James-Wilson/6000000000769960770Anne Adams: born in Northern Ireland in 1791:
https://www.geni.com/people/Anne-Wilson/6000000003075663777Thomas Woodrow: born in Scotland in 1793:
https://www.geni.com/people/Rev-Thomas-Woodrow/6000000007476641745Marion Williamson: born in Scotland in 1791:
https://www.geni.com/people/Marion-Woodrow/6000000007476767602So yeah, he presumably also had no ancestors living in the American colonies.