Besides Bernie Sanders? Maybe Mitch McConnell.
I'd say Cruz and McCain are far more well known than McConnell. This is by no means a perfect measure, but looking at Gallup's favorability tracker:
http://www.gallup.com/poll/1618/favorability-people-news.aspxin their August 2016 polling, only 8% of respondents had "never heard of" or had "no opinion of" Sanders, compared to 13% for Cruz. McCain hasn't been polled since August 2015, but his number at that time was 11%. McConnell was last polled in Oct. 2015, and his number was 40% having no opinion or never having heard of him.
My guess is that McCain would have been the most famous Senator as of ~18 months ago, but the 2016 election cycle introduced Sanders, Cruz, Rubio, Kaine, etc., with Sanders presumably now the most famous.