I'll just post that picture from 538.com...
It makes no sense to compare Ryan to VP nominees from the 1960s or earlier, since the presidential nomination process was vastly different back then, the rationale for why veeps were picked was different, and the job of vice president was different.
Also, even if you do try to use past performance of losing VP candidates to assess Ryan's chances of being his party's nominee in 2016, you have to account for the fact that unlike some of those past VP candidates, Ryan is young, popular within the party, and would face no other obvious "next in line" candidate in 2016. While it's too early to say whether Ryan would be the single frontrunner for the 2016 GOP nom., he'd almost certainly be one of the top leading contenders, unless he does terribly on the campaign trail in the coming months.